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Graefes Arch Clin Exp Ophthalmol (2007) 245:13871388 DOI 10.1007/s00417-007-0559-8
CASE REPORT
Elevated vascular endothelial growth factor levels in Coats disease: rapid response to pegaptanib sodium
Young Sun & Atul Jain & Darius M. Moshfeghi
Received: 11 January 2007 / Revised: 9 February 2007 / Accepted: 11 February 2007 / Published online: 7 March 2007 # Springer-Verlag 2007
Abstract Purpose The purpose was to report a case of elevated intraocular vascular endothelial growth factor (VEGF) levels in a 2-year-old boy with stage 4 Coats disease. Design Interventional case report. Methods A 2-year-old boy with severe Coats disease and complex retinal detachment refractory to surgical intervention underwent two injections of intravitreal pegaptanib sodium in his right eye 8 weeks apart. Results After intravitreal injection there was a marked reduction in VEGF (908 to 167 pg/ml) levels and improvement of exudation, hemorrhage, and nearly complete reattachment of his retina within 3 weeks of treatment. The patient remains stable 6 months post-treatment. Conclusions Coats disease may have a component of dysregulation of VEGF-mediated angiogenesis as evidenced by elevated levels in this patient.
Keywords VEGF levels . Pediatric VEGF levels . Coats disease . Pegaptanib sodium
Introduction
Coats disease, a rare non-hereditary vascular proliferative disease characterized by formation of retinal telangiectasia and exudation, primarily affects boys within the first decade of life [1]. While the etiology for Coats...