Abstract

Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and osteoarthritis-related knee pain in the Rotterdam Study; a large population based cohort study. We show that abundance of Streptococcus species is associated with increased knee pain, which we validate by absolute quantification of Streptococcus species. In addition, we replicate these results in 867 Caucasian adults of the Lifelines-DEEP study. Finally we show evidence that this association is driven by local inflammation in the knee joint. Our results indicate the microbiome is a possible therapeutic target for osteoarthritis-related knee pain.

Details

Title
Intestinal microbiome composition and its relation to joint pain and inflammation
Author
Boer, Cindy G 1   VIAFID ORCID Logo  ; Djawad Radjabzadeh 1 ; Medina-Gomez, Carolina 1   VIAFID ORCID Logo  ; Garmaeva, Sanzhima 2   VIAFID ORCID Logo  ; Schiphof, Dieuwke 3   VIAFID ORCID Logo  ; Arp, Pascal 1 ; Koet, Thomas 1 ; Kurilshikov, Alexander 2   VIAFID ORCID Logo  ; Fu, Jingyuan 4   VIAFID ORCID Logo  ; Ikram, M Arfan 5   VIAFID ORCID Logo  ; Bierma-Zeinstra, Sita 6 ; Uitterlinden, André G 7   VIAFID ORCID Logo  ; Kraaij, Robert 1 ; Zhernakova, Alexandra 2 ; Joyce B J van Meurs 1 

1  Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands 
2  Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands 
3  Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, the Netherlands 
4  Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands 
5  Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 
6  Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Orthopedics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 
7  Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 
Pages
1-9
Publication year
2019
Publication date
Oct 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-019-12873-4
ProQuest document ID
2309515098
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.