Content area

Abstract

‘BLAST 2 Sequences’, a new BLAST-based tool for aligning two protein or nucleotide sequences, is described. While the standard BLAST program is widely used to search for homologous sequences in nucleotide and protein databases, one often needs to compare only two sequences that are already known to be homologous, coming from related species or, e.g. different isolates of the same virus. In such cases searching the entire database would be unnecessarily time-consuming. ‘BLAST 2 Sequences’ utilizes the BLAST algorithm for pairwise DNA-DNA or protein-protein sequence comparison. A World Wide Web version of the program can be used interactively at the NCBI WWW site (http://www.ncbi.nlm.nih.gov/gorf/bl2.html). The resulting alignments are presented in both graphical and text form. The variants of the program for PC (Windows), Mac and several UNIX-based platforms can be downloaded from the NCBI FTP site (ftp://ncbi.nlm.nih.gov).

Details

Title
BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences
Author
Tatusova, Tatiana A 1 ; Madden, Thomas L 1 

 National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA 
Pages
247-250
Publication year
1999
Publication date
May 1999
Publisher
Oxford University Press
ISSN
03781097
e-ISSN
15746968
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2311751903
Copyright
© 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.