Content area

Abstract

Objectives

To explore potential effects of recombinant peptidyl-prolyl isomerase human Cyclophilin A (CypA) in the growth of mouse hair and human hair follicle dermal papilla cells (HDP).

Results

The hair growth of 8-weeks C57BL/6 mouse was significantly stimulated by recombinant human CypA protein. CypA also promoted Human Dermal Papilla (HDP) cell growth and induced β-catenin protein through GSK3β inhibition.

Conclusions

The molecular chaperone CypA stimulates hair follicle and HDP cells through Wnt/β-catenin signaling pathway, suggesting that it might be a key molecule for hair loss disorder therapy.

Details

Title
Recombinant human Cyclophilin A stimulates hair follicle cells via Wnt/β-catenin signaling pathway
Author
Kim, Kiyoon 1 ; Choe, Wonchae 2   VIAFID ORCID Logo 

1  Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea 
2  Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea; Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea; Department of Biochemistry and Molecular Biology, Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea 
Pages
1451-1458
Publication year
2019
Publication date
Dec 2019
Publisher
Springer Nature B.V.
ISSN
0141-5492
e-ISSN
1573-6776
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s10529-019-02751-w
ProQuest document ID
2311915805
Copyright
Biotechnology Letters is a copyright of Springer, (2019). All Rights Reserved.