Abstract

Human papillomavirus (HPV) infection correlates with higher rates of HIV acquisition, but the underlying biological mechanisms are unclear. Here we study associations between HPV and HIV acquisition and relate these to vaginal cytokine profiles in an observational cohort of women at high risk of HIV infection (CAPRISA 004, n = 779) and with 74% HPV prevalence. We report here that HPV infection associates with a 2.5-fold increase in HIV acquisition risk in this population (95% CI: 1.2–5.3). Among 48 vaginal cytokines profiled, cytokines associated with HPV infection overlap substantially with cytokines associated with HIV risk, but are distinct from those observed in HPV negative women. Although our data do not establish a causative link between HPV status and the risk of HIV, we suggest that increasing HPV vaccination coverage may carry an additional benefit of reducing the risk of contracting HIV infection, particularly in regions with high HPV prevalence.

Details

Title
HPV infection and the genital cytokine milieu in women at high risk of HIV acquisition
Author
Liebenberg, Lenine J P 1 ; McKinnon, Lyle R 2 ; Yende-Zuma, Nonhlanhla 3 ; Garrett, Nigel 3   VIAFID ORCID Logo  ; Baxter, Cheryl 3   VIAFID ORCID Logo  ; Kharsany, Ayesha B M 1   VIAFID ORCID Logo  ; Archary, Derseree 1 ; Rositch, Anne 4 ; Samsunder, Natasha 3 ; Mansoor, Leila E 3   VIAFID ORCID Logo  ; Passmore, Jo-Ann S 5   VIAFID ORCID Logo  ; Salim S Abdool Karim 6 ; Karim, Quarraisha Abdool 6   VIAFID ORCID Logo 

1  Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa 
2  Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada 
3  Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa 
4  Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 
5  Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Institute of Infectious Disease and Molecular Medicine (IDM) and MRC-UCT Gynecological Cancer Research Centre, University of Cape Town, Cape Town, South Africa; National Health Laboratory Service, Cape Town, South Africa 
6  Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa; Department of Epidemiology, Columbia University, New York City, NY, USA 
Pages
1-12
Publication year
2019
Publication date
Nov 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-019-13089-2
ProQuest document ID
2315953645
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.