It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Diarrhea remains one of the most common causes of deaths in children. Although many studies have investigated the prevalence of enteric pathogens around the globe some diarrheal episodes remain unexplained. It is possible that some yet-unidentified viral agents could be related to these cases of gastroenteritis. By using viral metagenomics techniques, we screened 251 fecal samples of children between 0.5 to 2.5-year-old with acute diarrhea not associated with common pathogens. These children live in rural areas and have different levels of contact with animals such as pigs, cows and bats. Here we report a complete genome of one mammalian orthoreovirus (MRV) type 3, denoted TO-151/BR, detected in a female child in the state of Tocantins (north of Brazil). Brazilian TO-151/BR strain was classified as MRV-3 based on S1 phylogeny and was closely related to porcine Asian strains. Phylogenetic analyses showed that other segments were more similar to MRV-3s of different geographic locations and hosts, including human and bats, highlighting genome reassortment and lack of host-specific barriers. This is the first report of MRV-3 in South America and a hypothesis of a silent long-term circulation of this virus in Brazil has been raised.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 Institute of Biological Sciences, Federal University of Para, Para, Brazil
2 Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, Sao Paulo, Brazil
3 Secretary of Health of Tocantins, Tocantins, Brazil; Institute of Biological Sciences, Federal University of Tocantins, Tocantins, Brazil; Public Health Laboratory of Tocantins State (LACEN/TO), Tocantins, Brazil
4 Postgraduate Program in Health Science, Faculty of Medicine of ABC, Santo André, Brazil; Retrovirology Laboratory, Federal University of São Paulo, São Paulo, Brazil
5 Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil; Polytechnic School of University of Sao Paulo, Sao Paulo, Brazil
6 Secretary of Health of Tocantins, Tocantins, Brazil; Public Health Laboratory of Tocantins State (LACEN/TO), Tocantins, Brazil
7 Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
8 Centre for Drug Design Discovery and Development (C4D), SRM University, Delhi-NCR, Rajiv Gandhi Education City, Sonepat, Haryana, India
9 Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil; LIM/46, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
10 Vitalant Research Institute, San Francisco, CA, USA; Department Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA
11 Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil