Abstract/Details

Some Aspects on Novel Heterocyclic Compounds and Their Microbicidal Activity

Pandya, Keyur M.  Veer Narmad South Gujarat University. ProQuest Dissertations Publishing, 2019. 27750600.

Abstract (summary)

Heterocyclic compounds play an important role in medicinal chemistry. Motifs such as imidazoles, pyrazoles, quinolines, azetidinones, thiazolidinones, pyrrolidinones, dihydropyrrolones, hydrazones, triazoles, oxadiazoles, etc. are routinely observed in several compounds of pharmacological interest. Several natural products also contain these motifs in them. We have undertaken a library synthesis of heterocyclic molecules driven by our group's long-standing interest of synthesizing medicinally relevant small molecules employing simple chemistry techniques. This thesis details our efforts on the development of novel synthetic methodologies for the synthesis of functionalized heterocyclic compounds as potential antibacterial, antifungal, anti-mycobacterial and antimalarial agents. We initiated the synthesis of these compounds employing traditional chemistry reaction and one-pot synthesis strategy as the key steps. The biological evaluation of these synthetic derivatives showed some promise as antibacterial, antifungal, anti-mycobacterial and antimalarial agents.

Indexing (details)


Subject
Microbiology;
Pharmacology;
Biochemistry;
Organic chemistry
Classification
0487: Biochemistry
0410: Microbiology
0419: Pharmacology
0490: Organic chemistry
Identifier / keyword
Heterocyclic compounds; Medicinal chemistry; Dihydropyrrolone conjugates
Title
Some Aspects on Novel Heterocyclic Compounds and Their Microbicidal Activity
Author
Pandya, Keyur M.
Number of pages
343
Degree date
2019
School code
2098
Source
DAI-B 81/6(E), Dissertation Abstracts International
Place of publication
Ann Arbor
Country of publication
United States
ISBN
9781392665763
Advisor
Desai, Piyush S.
Committee member
Patel, Arunkumar L.
University/institution
Veer Narmad South Gujarat University
University location
India
Degree
Ph.D.
Source type
Dissertation or Thesis
Language
English
Document type
Dissertation/Thesis
Dissertation/thesis number
27750600
ProQuest document ID
2323407896
Copyright
Copyright ProQuest Dissertations Publishing 2019
Document URL
https://www.proquest.com/docview/2323407896