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Abstract
Heterocyclic compounds play an important role in medicinal chemistry. Motifs such as imidazoles, pyrazoles, quinolines, azetidinones, thiazolidinones, pyrrolidinones, dihydropyrrolones, hydrazones, triazoles, oxadiazoles, etc. are routinely observed in several compounds of pharmacological interest. Several natural products also contain these motifs in them. We have undertaken a library synthesis of heterocyclic molecules driven by our group's long-standing interest of synthesizing medicinally relevant small molecules employing simple chemistry techniques. This thesis details our efforts on the development of novel synthetic methodologies for the synthesis of functionalized heterocyclic compounds as potential antibacterial, antifungal, anti-mycobacterial and antimalarial agents. We initiated the synthesis of these compounds employing traditional chemistry reaction and one-pot synthesis strategy as the key steps. The biological evaluation of these synthetic derivatives showed some promise as antibacterial, antifungal, anti-mycobacterial and antimalarial agents.
