Abstract

During viral infection, virus-derived cytosolic nucleic acids are recognized by host intracellular specific sensors. The efficacy of this recognition system is crucial for triggering innate host defenses, which then stimulate more specific adaptive immune responses against the virus. Recent studies show that signal transduction pathways activated by sensing proteins are positively or negatively regulated by many modulators to maintain host immune homeostasis. However, viruses have evolved several strategies to counteract/evade host immune reactions. These systems involve viral proteins that interact with host sensor proteins and prevent them from detecting the viral genome or from initiating immune signaling. In this review, we discuss key regulators of cytosolic sensor proteins and viral proteins based on experimental evidence.

Details

Title
Intracellular sensing of viral genomes and viral evasion
Author
Lee, Hyun-Cheol 1 ; Chathuranga, Kiramage 2   VIAFID ORCID Logo  ; Jong-Soo, Lee 2 

1  College of Veterinary Medicine, Chungnam National University, Daejeon, Korea; Central Research Institute, Komipharm International Co., Ltd, Shiheung, Korea 
2  College of Veterinary Medicine, Chungnam National University, Daejeon, Korea 
Pages
1-13
Publication year
2019
Publication date
Dec 2019
Publisher
Springer Nature B.V.
ISSN
12263613
e-ISSN
20926413
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s12276-019-0299-y
ProQuest document ID
2324903787
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.