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Abstract
Diseases caused by Herpes Simplex viruses are worldwide spread. Long-term treatment of these diseases with known and widely used medicines leads to drug-resistant virus strains occurring. For this reason, research and development of novel anti-HSV medicines is a critical task now. There are two ways to invent and develop a new drug - design, and synthesis of new molecules for therapeutic purposes and production pharmacologically active plant-derived natural products. Hedysarum alpinum is one of those plants that contain a complex of bioactive substances which are pharmacologically active against HSV and have an immunostimulatory effect.
The purpose of the study is to develop a formulation and technology to obtain a semisolid dosage form which contains Hedysarum alpinum dry extract. The study includes results of choosing excipients and appearance, osmotic activity and aggregate stability tests. As a result of the study, a composition of the dosage form was selected.
Keywords: Herpes simplex virus, semisolid dosage form, ointment, Hedysarum alpinum.
Introduction
According to the WHO information, more than 3.7 billion people (67% of the population) of the world under the age of 50 are infected with various types of herpes viruses [5]. There are two types of herpes simplex virus (HSV) - type 1 herpes simplex virus (HSV-1) and type II herpes simplex virus (HSV-2). HSV-1 is transmitted mainly through oro-oral contact and causes orolabial herpes. HSV-2 is almost always sexually transmitted and causes genital herpes. However, according to the latest WHO data, HSV-1 also causes genital herpes [5]. As a result, it was revealed that more than half a billion people aged 15 to 49 years had a genital infection caused by either HSV-1 or HSV-2. There is no full recovery from these types of viruses and usually in the body HSV-1 is in a latent state. When it is activated, symptoms present with painful blisters or ulcers with different localization [6,7].
Among the various dosage forms for rectal treatment of HSV there is a promising ointment. It has several advantages over suppositories: the possibility of external use with little common effect on the body; the maximum concentration of the active substances at the site of the skin or mucous damage, where the risk of common side effects is minimal, and the ointment is convenient...