Abstract

Psychiatric disorders are often accompanied by alterations in BMI and body composition due to changes in eating behaviour and physical activity. Here, Hübel et al. study the genetic overlap between these traits and find that genetic correlations between psychiatric disorders and body composition are sex-specific and evident only in adulthood.

Details

Title
Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent
Author
Christopher Hübel 1   VIAFID ORCID Logo  ; Héléna A Gaspar 2   VIAFID ORCID Logo  ; Coleman, Jonathan R I 2   VIAFID ORCID Logo  ; Hanscombe, Ken B 3 ; Purves, Kirstin 4   VIAFID ORCID Logo  ; Prokopenko, Inga 5   VIAFID ORCID Logo  ; Graff, Mariaelisa 6 ; Ngwa, Julius S 7 ; Workalemahu, Tsegaselassie 8 ; Paul F O’Reilly 4   VIAFID ORCID Logo  ; Bulik, Cynthia M 9   VIAFID ORCID Logo  ; Breen, Gerome 2   VIAFID ORCID Logo 

 Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; UK National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, London, UK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden 
 Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; UK National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, London, UK 
 Department of Medical and Molecular Genetics, King’s College London, Guy’s Hospital, London, UK 
 Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK 
 Section of Statistical Multi-Omics, Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK 
 Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA 
 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA 
 Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA 
 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA 
Pages
1-12
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2328303934
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.