Abstract

Objective

NRK is a unique X chromosome-linked protein kinase expressed predominantly in placenta. The gene knockout causes placental overgrowth and delayed labor of Nrk-null fetuses from dams in mouse. To clarify unknown mechanisms behind the Nrk-null phenotypes, protein expression profiles were analyzed in the Nrk-null placenta using a high-performance two-dimensional electrophoresis methodology.

Results

Among around 1800 spots detected, we characterized a dozen protein spots whose expression levels were significantly altered in the Nrk-null placenta compared to wild-type. Analyzing these data sets is expected to reflect the difference physiologically in the presence or absence of NRK, facilitating the development of therapeutic strategies.

Details

Title
Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK
Author
Denda, Kimitoshi; Kanako Ida; Tanno, Masataka; Nakao-Wakabayashi, Kanako; Komada, Masayuki; Hayashi, Nobuhiro
Pages
1-5
Section
Research note
Publication year
2019
Publication date
2019
Publisher
BioMed Central
e-ISSN
17560500
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2328545126
Copyright
© 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.