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Abstract
The prevalence of cognitive decline is increasing as the ageing population is considerably growing. Restricting this age-associated process has become a challenging public health issue. The age-related increase in oxidative stress plays a major role in cognitive decline, because of its harmful effect on functional plasticity of the brain, such as long-term potentiation (LTP). Here, we show that citrulline (Cit) has powerful antioxidant properties that can limit ex vivo oxidative stress-induced LTP impairment in the hippocampus. We also illustrate that a three-month Cit supplementation has a protective effect on LTP in aged rats in vivo. The identification of a Cit oxidation byproduct in vitro suggests that the antioxidant properties of Cit could result from its own oxidation. Cit supplementation may be a promising preventive nutritional approach to limit age-related cognitive decline.
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1 Centre de Psychiatrie et Neurosciences, UMR_S894, INSERM, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Service de Biochimie, Hôpitaux Universitaires Paris-Centre, Hôpital Cochin, AP-HP, Paris, France; EA4466 Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
2 UMR CNRS 8638 COMETE - Chimie Toxicologie Analytique et Cellulaire, Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
3 EA4466 Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Laboratoire de bioénergétique fondamentale et appliquée, Université Grenoble Alpes, INSERM U1055, Grenoble, France
4 Service de Biochimie, Hôpitaux Universitaires Paris-Centre, Hôpital Cochin, AP-HP, Paris, France; EA4466 Laboratoire de Biologie de la Nutrition, Faculté de Pharmacie de Paris, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
5 Centre de Psychiatrie et Neurosciences, UMR_S894, INSERM, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
6 Centre de Psychiatrie et Neurosciences, UMR_S894, INSERM, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Biophotonics and Synapse Physiopathology, Laboratoire Aimé Cotton, CNRS, Université Paris-Sud, ENS Cachan, and Université Paris-Saclay, Orsay, France