Content area
Abstract
Chalcone is an aromatic ketone that forms the central core of many important biological compounds, which are known as chalcones. Chalcones are the biogenetic precursors of flavonoids and isoflavonoids, which are abundant in plants. Chalcones are active lead molecules in medicinal chemistry for the discovery of new drugs. Here, we review properties, biosynthesis and structural diversity of natural chalcones. Then, we present the synthesis of chalcones and their biological activities with focus on structure–activity relationships. Pharmaceutically important and patented chalcones are also discussed.
Details
Title
Chalcone synthesis, properties and medicinal applications: a review
Author
Aluru, Rammohan 1
; Reddy, Julakanti Satyanarayana 2 ; Gundala, Sravya 3 ; Rao, Chittluri Narasimha 4 ; Zyryanov, Grigory V 5
1 Ural Federal University, Department of Organic and Biomolecular Chemistry, Yekaterinburg, Russian Federation (GRID:grid.412761.7) (ISNI:0000 0004 0645 736X); Sri Venkateswara University, Department of Chemistry, Tirupati, India (GRID:grid.412313.6) (ISNI:0000 0001 2154 622X)
2 National Health Research Institute, Zhunan, Taiwan (GRID:grid.59784.37) (ISNI:0000000406229172)
3 Ural Federal University, Department of Organic and Biomolecular Chemistry, Yekaterinburg, Russian Federation (GRID:grid.412761.7) (ISNI:0000 0004 0645 736X)
4 Sri Venkateswara University, Department of Chemistry, Tirupati, India (GRID:grid.412313.6) (ISNI:0000 0001 2154 622X)
5 Ural Federal University, Department of Organic and Biomolecular Chemistry, Yekaterinburg, Russian Federation (GRID:grid.412761.7) (ISNI:0000 0004 0645 736X); I. Ya. Postovskiy Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, Yekaterinburg, Russian Federation (GRID:grid.465347.7)
; Reddy, Julakanti Satyanarayana 2 ; Gundala, Sravya 3 ; Rao, Chittluri Narasimha 4 ; Zyryanov, Grigory V 5 1 Ural Federal University, Department of Organic and Biomolecular Chemistry, Yekaterinburg, Russian Federation (GRID:grid.412761.7) (ISNI:0000 0004 0645 736X); Sri Venkateswara University, Department of Chemistry, Tirupati, India (GRID:grid.412313.6) (ISNI:0000 0001 2154 622X)
2 National Health Research Institute, Zhunan, Taiwan (GRID:grid.59784.37) (ISNI:0000000406229172)
3 Ural Federal University, Department of Organic and Biomolecular Chemistry, Yekaterinburg, Russian Federation (GRID:grid.412761.7) (ISNI:0000 0004 0645 736X)
4 Sri Venkateswara University, Department of Chemistry, Tirupati, India (GRID:grid.412313.6) (ISNI:0000 0001 2154 622X)
5 Ural Federal University, Department of Organic and Biomolecular Chemistry, Yekaterinburg, Russian Federation (GRID:grid.412761.7) (ISNI:0000 0004 0645 736X); I. Ya. Postovskiy Institute of Organic Synthesis, Ural Division of the Russian Academy of Sciences, Yekaterinburg, Russian Federation (GRID:grid.465347.7)
Pages
433-458
Publication year
2020
Publication date
Mar 2020
ISSN
16103653
e-ISSN
16103661
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2366192636
Copyright
Environmental Chemistry Letters is a copyright of Springer, (2020). All Rights Reserved.