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Abstract
Reduced pancreas volume, as measured by non-contrast magnetic resonance imaging (MRI), is observed in individuals with newly-diagnosed type 1 diabetes (T1D) and declines over the first year after diagnosis. In this study, we determined the repeatability and inter-reader reproducibility of pancreas volume measurements by MRI. Test-retest scans in individuals with or without T1D (n = 16) had an intraclass correlation coefficient (ICC) of 0.985 (95% CI 0.961 to 0.995) for pancreas volume. Independent pancreas outlines by two board-certified radiologists (n = 30) yielded an ICC of 0.945 (95% CI 0.889 to 0.973). The mean Dice coefficient, a measurement of the degree of overlap between pancreas regions of interest between the two readers, was 0.77. Prandial state did not influence pancreatic measurements, as stomach volume did not correlate with pancreas volume. These data demonstrate that MRI measurements of pancreas volume between two readers are repeatable and reproducible with ICCs that correspond to excellent clinical significance (ICC > 0.9), are not related to changes in stomach volume, and could be a useful tool for clinical investigation of diabetes and other pancreas pathologies.
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1 Vanderbilt University Medical Center, Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
2 Vanderbilt University Medical Center, Department of Radiology and Radiological Sciences, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916); Vanderbilt University Medical Center, Department of Pediatrics, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
3 University of Texas at Austin, Department of Electrical and Computer Engineering, Austin, USA (GRID:grid.89336.37) (ISNI:0000 0004 1936 9924)
4 University of Texas at Austin, Department of Diagnostic Medicine, Dell Medical School, Austin, USA (GRID:grid.89336.37) (ISNI:0000 0004 1936 9924)
5 Vanderbilt University Medical Center, Department of Biostatistics, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916)
6 Vanderbilt University Medical Center, Department of Pediatrics, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916); Vanderbilt University, Department of Cell and Developmental Biology, Nashville, USA (GRID:grid.152326.1) (ISNI:0000 0001 2264 7217)
7 Vanderbilt University Medical Center, Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916); Vanderbilt University, Department of Molecular Physiology and Biophysics, Nashville, USA (GRID:grid.152326.1) (ISNI:0000 0001 2264 7217); VA Tennessee Valley Healthcare System, Nashville, USA (GRID:grid.452900.a) (ISNI:0000 0004 0420 4633)
8 Vanderbilt University Medical Center, Department of Pediatrics, Nashville, USA (GRID:grid.412807.8) (ISNI:0000 0004 1936 9916); Vanderbilt University, Department of Pathology, Immunology, and Microbiology, Nashville, USA (GRID:grid.152326.1) (ISNI:0000 0001 2264 7217)
9 University of Texas at Austin, Department of Diagnostic Medicine, Dell Medical School, Austin, USA (GRID:grid.89336.37) (ISNI:0000 0004 1936 9924); Livestrong Cancer Institutes, Dell Medical School, University of Texas at Austin, Austin, USA (GRID:grid.89336.37) (ISNI:0000 0004 1936 9924); University of Texas at Austin, Department of Oncology, Dell Medical School, Austin, USA (GRID:grid.89336.37) (ISNI:0000 0004 1936 9924)