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Abstract
Sarcopenia is characterized by low skeletal muscle, a complex trait with high heritability. With the dramatically increasing prevalence of obesity, obesity and sarcopenia occur simultaneously, a condition known as sarcopenic obesity. Fat mass and obesity-associated (FTO) gene is a candidate gene of obesity. To identify associations between lean mass and FTO gene, we performed a genome-wide association study (GWAS) of lean mass index (LMI) in 2207 unrelated Caucasian subjects and replicated major findings in two replication samples including 6,004 unrelated Caucasian and 38,292 unrelated Caucasian. We found 29 single nucleotide polymorphisms (SNPs) in FTO significantly associated with sarcopenia (combined p-values ranging from 5.92 × 10−12 to 1.69 × 10−9). Potential biological functions of SNPs were analyzed by HaploReg v4.1, RegulomeDB, GTEx, IMPC and STRING. Our results provide suggestive evidence that FTO gene is associated with lean mass.
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1 University of Shanghai for Science and Technology, School of Medical Instruments and Food Engineering, Shanghai, P.R. China (GRID:grid.267139.8) (ISNI:0000 0000 9188 055X)
2 Soochow University, Center for Genetic Epidemiology and Genomics, School of Public Health, Jiangsu, P.R. China (GRID:grid.267139.8); Soochow University, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Jiangsu, P.R. China (GRID:grid.267139.8)
3 Soochow University, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Jiangsu, P.R. China (GRID:grid.267139.8); Soochow University, Department of Epidemiology and Statistics, School of Public Health, Jiangsu, P.R. China (GRID:grid.267139.8)
4 Beijing Gene Tangram Technology Development CO., Ltd., Beijing, P.R. China (GRID:grid.267139.8)
5 Inner Mongolia Autonomous Region Center of Health Management Service, Hohhot, P.R. China (GRID:grid.267139.8)
6 Ji Lin University, First Hospital, Changchun, P.R. China (GRID:grid.267139.8)
7 Tulane University, Department of Biostatistics and Data Science, New Orleans, USA (GRID:grid.265219.b) (ISNI:0000 0001 2217 8588)
8 Soochow University, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Jiangsu, P.R. China (GRID:grid.265219.b); Soochow University, Department of Epidemiology and Statistics, School of Public Health, Jiangsu, P.R. China (GRID:grid.265219.b)
9 Ji Lin University, First Hospital, Changchun, P.R. China (GRID:grid.265219.b)