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© 2017. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Herb-partitioned moxibustion can effectively mitigate visceral pain, a major symptom in inflammatory bowel disease, but the analgesic mechanism is still unclear. Moreover, extracellular signal-regulated kinase, substance P, and neurokinin-1 are involved in formation of central hyperalgesia. Thus, we postulated that the analgesic effect of herb-partitioned moxibustion may be associated with these factors. Accordingly, in this study, we established an inflammatory bowel disease visceral pain model in rat by enema with a mixed solution of 5% trinitrobenzenesulfonic acid and 50% ethanol. Bilateral Tianshu (ST25) and Qihai (CV6) points were selected for herb-partitioned moxibustion. Our results showed that herb-partitioned moxibustion improved visceral pain and down-regulated extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and mRNA expression in dorsal root ganglia. These results indicate that down-regulation of extracellular signal-regulated kinase, substance P, and neurokinin-1 protein and mRNA may be a central mechanism for the analgesic effect of herb-partitioned moxibustion.

Details

Title
Extracellular signal-regulated kinase, substance P and neurokinin-1 are involved in the analgesic mechanism of herb-partitioned moxibustion
Author
Zhi-yuan, Li 1 ; Yan-ting, Yang 2 ; Hong, Jue 3 ; Zhang, Dan 4 ; Xiao-fei, Huang 2 ; Li-jie, Wu 2 ; Huan-gan Wu 4 ; Shi, Zheng 3 ; Liu, Jie 3 ; Zhu, Yi 3 ; Xiao-peng, Ma 4 

 Shanghai University of Traditional Chinese Medicine, Shanghai; Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province 
 Shanghai University of Traditional Chinese Medicine, Shanghai 
 Shanghai Research Institute of Acupuncture and Meridian, Shanghai 
 Shanghai University of Traditional Chinese Medicine, Shanghai; Shanghai Research Institute of Acupuncture and Meridian, Shanghai 
Pages
1472-1478
Publication year
2017
Publication date
Sep 2017
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
16735374
e-ISSN
18767958
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2382706732
Copyright
© 2017. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.