Amino-functionalized cellulose: a novel and high-efficiency scavenger for sodium cholate sorption

Abstract

In this work, a novel and high-efficiency scavenger based on amino-functionalized cellulose was designed for sodium cholate sorption in vitro. To estimate the adsorption performance of the amino-functionalized cellulose for sodium cholate, various factors including sodium cholate concentration, contact time and electrolyte were investigated. The results suggested that amino-functionalization for cellulose regarding to hyperbranched polyethylenimine not only induce positive charge surface of cellulose but also provide abundant and special binding sites for sodium cholate sorption. The amino-functionalized cellulose displayed an excellent performance to sodium cholate sorption with a maximum adsorption capacity of 569.7 mg/g, higher than cholestyramine, a synthetic lipid-lowering drug in clinic. And the adsorption behavior was well fitted into the Langmuir isotherm model and pseudo-second-order kinetic model, suggesting a homogeneous monolayer chemisorption. Furthermore, the amino-functionalized cellulose presented the features of excellent anti-interferences, cytocompatibility and facile preparation process. All these results support amino-functionalized cellulose as a promising prospect for cholesterol elimination.