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Abstract
Effects of diphenyl difluoroketone (EF-24) and curcumin on cell growth and apoptosis induction in KB human oral cancer cells were examined. EF-24 and curcumin inhibited the growth of KB cells in a dose-dependent manner, and the potency of EF-24 was 30 times greater than that of curcumin. Treatment with EF-24 or curcumin resulted in nuclear condensation and fragmentation. EF-24 and curcumin promoted the proteolytic cleavage of procaspases-3, -7, and -9. Activities of caspases-3 and -7 were detected in living KB cells treated with EF-24 or curcumin. These results suggest that EF-24 and curcumin inhibit cell proliferation and induce apoptosis in KB human oral cancer cells, and have potential properties for development of anti oral cancer drug.
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1 Chosun University School of Dentistry, Oral Biology Research Institute, Gwangju, Republic of Korea (GRID:grid.254187.d) (ISNI:0000000094758840)
2 Chosun University, Regional Innovation Center for Dental Science & Engineering, Gwangju, Republic of Korea (GRID:grid.254187.d) (ISNI:0000000094758840)
3 Chosun University School of Dentistry, Oral Biology Research Institute, Gwangju, Republic of Korea (GRID:grid.254187.d) (ISNI:0000000094758840); Chosun University, Regional Innovation Center for Dental Science & Engineering, Gwangju, Republic of Korea (GRID:grid.254187.d) (ISNI:0000000094758840)
4 Chosun University, Department of Biotechnology, Gwangju, Republic of Korea (GRID:grid.254187.d) (ISNI:0000000094758840)
5 Chosun University School of Dentistry, Oral Biology Research Institute, Gwangju, Republic of Korea (GRID:grid.254187.d) (ISNI:0000000094758840); Chosun University, Department of Biotechnology, Gwangju, Republic of Korea (GRID:grid.254187.d) (ISNI:0000000094758840)