Content area
Abstract
The EtOAc fraction of Rhodiola rosea ethanolic extracts showed a strong antioxidant activity. Through activity-guided fractionation and purification, we isolated two flavonol glycosides, which were identified as the well known flavonoids, rhodionin (1) and rhodiosin (2). To compare their antioxidant activities, we used an authentic aglycone compound, herbacetin (3). Among the compounds tested, rhodiosin (2) exhibited strong antioxidant activity, with IC50 values of 0.21 and 0.15 μM against •OH and •O-2, respectively. Rhodiosin (2) (100 mg/kg) reduced MDA content in the liver induced by irradiation when given prior to exposure of γ-radiation.
Details
Title
Rhodiosin, an Antioxidant Flavonol Glycoside from Rhodiola rosea
Author
Hyung-Jun, Kwon 1 ; Ryu Young Bae 1 ; Jeong, Hyung Jae 1 ; Kim, Jang Hoon 1 ; Su-Jin, Park 1 ; Chang Jong Sun 1 ; Kim, Minsoo 1 ; Mun-Chual, Rho 1 ; Lee Woo Song 1
1 Korea Research Institute of Bioscience and Biotechnology (KRIBB), Bioindustry Technical Research Center and AI Control Material Research Center, Jeongeup, (GRID:grid.249967.7) (ISNI:0000000406363099)
1 Korea Research Institute of Bioscience and Biotechnology (KRIBB), Bioindustry Technical Research Center and AI Control Material Research Center, Jeongeup, (GRID:grid.249967.7) (ISNI:0000000406363099)
Pages
486-492
Publication year
2009
Publication date
Oct 2009
ISSN
17382203
e-ISSN
2234344X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2399177765
Copyright
© Springer-Verlag 2003.