Content area
Abstract
One secoiridoid glycoside was isolated from the EtOAc-soluble fraction of flowers of Osmanthus fragrans var. aurantiacus by repeated silica gel, octadecyl silica gel (ODS) and Sephadex LH-20 column chromatographies. It was identified as (8E)-ligstroside based on spectroscopic methods including NMR and MS. This compound has been first isolated from Osmanthus fragrans var. aurantiacus, and showed BACE1 inhibition activity.
Details
Title
Secoiridoid glycoside from the flowers of Osmanthus fragrans var. aurantiacus makino inhibited the activity of β-secretase
Author
Do-Gyeong, Lee 1 ; Jin-Sung, Choi 2 ; Seung-Woo, Yeon 2 ; En-Ji, Cui 1 ; Hee-Jung, Park 1 ; Jong-Su, Yoo 2 ; Chung In-Sik 1 ; Baek Nam-In 1
1 Kyung Hee University, Graduate School of Biotechnology & Institute of Life Sciences & Resources, Yongin, (GRID:grid.289247.2) (ISNI:0000000121717818)
2 Ildong Pharmaceutical Co. Ltd., Research Laboratories, Hwaseong, (GRID:grid.497705.8) (ISNI:0000 0004 0648 021X)
1 Kyung Hee University, Graduate School of Biotechnology & Institute of Life Sciences & Resources, Yongin, (GRID:grid.289247.2) (ISNI:0000000121717818)
2 Ildong Pharmaceutical Co. Ltd., Research Laboratories, Hwaseong, (GRID:grid.497705.8) (ISNI:0000 0004 0648 021X)
Pages
371-374
Publication year
2010
Publication date
Jun 2010
ISSN
17382203
e-ISSN
2234344X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2399178525
Copyright
© Springer-Verlag 2003.