Content area
Abstract
Anthranilic acid derivatives (3–5) containing the long chain components of N-stearoyl, -oleoyl, and-linoleoyl groups were synthesized for the study of prolyl endopeptidase (PEP, EC 3.4.21.26) inhibitory activity. Compounds 3–5 showed competitive PEP inhibition with IC50 values of 2.81, 4.07 and 3.64 μM, respectively, and Ki values of 1.62, 4.10 and 2.77 μM, respectively.
Details
Title
Synthesis of anthranilic acid derivatives as prolyl endopeptidase inhibitors
Author
Han Hyun-Gyu 1 ; Yoon Hye-Ryeon 1 ; Young-Sook, Paik 1
1 Kyung Hee University, Department of Applied Chemistry, Yongin, (GRID:grid.289247.2) (ISNI:0000000121717818)
1 Kyung Hee University, Department of Applied Chemistry, Yongin, (GRID:grid.289247.2) (ISNI:0000000121717818)
Pages
735-738
Publication year
2009
Publication date
Dec 2009
ISSN
17382203
e-ISSN
2234344X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2399178903
Copyright
© Springer-Verlag 2003.