Content area
Abstract
Cytochrome P450IIE1 (P450IIE1) is involved in metabolic activation of carcinogenic nitrosamines, aniline and benzene. We detected a restriction fragment length polymorphism of the human P450IIE1 gene with the restriction endonuclease Oral. The population was thus divided into three genotypes, namely, heterozygotes (CD) and two forms of homozygotes (CC and DD). The distribution of these genotypes among lung cancer patients differed front that among controls with statistical significance of P< 0.05 (x2=7.01 with 2 degrees of freedom). This result strongly suggests that host susceptibility to lung cancer is associated with the Dral polymorphism of the P450IIE1 gene.
Details
Title
Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer
Author
Uematsu, Fumiyuki 1 ; Kikuchi, Hideaki 2 ; Motomiya, Masakichi 3 ; Abe, Tatsuya 3 ; Sagami, Ikuko 2 ; Ohmachi, Tetsuo 2 ; Wakui, Akira 4 ; Kanamaru, Ryunosuke 4 ; Watanabe, Minro 2
1 Department of Cancer Chemotherapy and Prevention, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980; Department of Internal Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
2 Department of Cancer Chemotherapy and Prevention, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
3 Department of Internal Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
4 Department of Clinical Cancer Chemotherapy, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
1 Department of Cancer Chemotherapy and Prevention, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980; Department of Internal Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
2 Department of Cancer Chemotherapy and Prevention, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
3 Department of Internal Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
4 Department of Clinical Cancer Chemotherapy, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980
Section
RAPID COMMUNICATION
Publication year
1991
Publication date
Mar 1991
ISSN
09105050
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2400013230
Copyright
Copyright John Wiley & Sons, Inc. Mar 1991