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Abstract
Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun mat loaded with berberine (Beri) as the DFU-specific wound dressing. The wound healing efficacy of the fabricated dressings was evaluated in streptozotocin-induced diabetic rats. The results demonstrated an average nanofiber diameter of 502 ± 150 nm, and the tensile strength, contact angle, porosity, water vapor permeability and water uptake ratio of CA/Gel nanofibers were around 2.83 ± 0.08 MPa, 58.07 ± 2.35°, 78.17 ± 1.04%, 11.23 ± 1.05 mg/cm2/hr, and 12.78 ± 0.32%, respectively, while these values for CA/Gel/Beri nanofibers were 2.69 ± 0.05 MPa, 56.93 ± 1°, 76.17 ± 0.76%, 10.17 ± 0.21 mg/cm2/hr, and 14.37 ± 0.42%, respectively. The antibacterial evaluations demonstrated that the dressings exhibited potent antibacterial activity. The collagen density of 88.8 ± 6.7% and the angiogenesis score of 19.8 ± 3.8 obtained in the animal studies indicate a proper wound healing. These findings implied that the incorporation of berberine did not compromise the physical properties of dressing, while improving the biological activities. In conclusion, our results indicated that the prepared mat is a proper wound dressing for DFU management and treatment.
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1 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran (GRID:grid.412112.5) (ISNI:0000 0001 2012 5829)
2 York University, Department of Kinesiology and Health Science, Ontario, Canada (GRID:grid.21100.32) (ISNI:0000 0004 1936 9430)
3 Science and Research Branch, Islamic Azad University, Department of Mechanical Engineering, Tehran, Iran (GRID:grid.472472.0)
4 Tehran University of Medical Sciences, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran, Iran (GRID:grid.411705.6) (ISNI:0000 0001 0166 0922)
5 Shiraz University of Medical Sciences, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz, Iran (GRID:grid.412571.4) (ISNI:0000 0000 8819 4698)
6 Shahroud University of Medical Sciences, School of Medicine, Shahroud, Iran (GRID:grid.444858.1) (ISNI:0000 0004 0384 8816)
7 Dental School, Shahid Beheshti University of Medical sciences, Department of Oral and Maxillofacial Surgery, Tehran, Iran (GRID:grid.411600.2)
8 Dental student of scientific research center, faculty of dentistry, Tehran university of medical sciences, Tehran, Iran (GRID:grid.411705.6) (ISNI:0000 0001 0166 0922)
9 Department of Biomedical Engineering, Rochester Institute of Technology, Rochester, USA (GRID:grid.262613.2) (ISNI:0000 0001 2323 3518); Rochester Institute of Technology, Department of Microsystems Engineering, Rochester, USA (GRID:grid.262613.2) (ISNI:0000 0001 2323 3518)
10 School of Advanced Technologies, Fasa University of Medical Sciences, Department of Tissue Engineering, Fasa, Iran (GRID:grid.411135.3) (ISNI:0000 0004 0415 3047)
11 Shahroud University of Medical Sciences, Department of Tissue Engineering, School of Medicine, Shahroud, Iran (GRID:grid.444858.1) (ISNI:0000 0004 0384 8816); Tissue Engineering and stem cells research center, Shahroud University of Medical Sciences, Shahroud, Iran (GRID:grid.444858.1) (ISNI:0000 0004 0384 8816)