Abstract

Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

Graphic Abstract

Details

Title
Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile
Author
Hui-Min, Zhou 1 ; Yan-Song, Ye 1 ; Na-Na, Jiang 1 ; Rong-Fang, Mu 1 ; Wang, Qian 1 ; Hu, Jing 2 ; Liu, Xia 3 ; Wan-Ying, Qin 1 ; Xu, Gang 1 ; Wen-Yong, Xiong 1   VIAFID ORCID Logo 

1  Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming, People’s Republic of China (GRID:grid.458460.b) (ISNI:0000 0004 1764 155X); University of Chinese Academy of Sciences, Beijing, People’s Republic of China (GRID:grid.410726.6) (ISNI:0000 0004 1797 8419) 
2  Kunming Institute of Botany, Chinese Academy of Sciences, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming, People’s Republic of China (GRID:grid.458460.b) (ISNI:0000 0004 1764 155X) 
3  Chongqing Traditional Chinese Medicine Hospital, Department of Pharmacy, Chongqing, China (GRID:grid.458460.b) 
Pages
163-170
Publication year
2020
Publication date
Jun 2020
Publisher
Springer Nature B.V.
ISSN
21922195
e-ISSN
21922209
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s13659-020-00245-1
ProQuest document ID
2407212555
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.