Abstract

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

Details

Title
The fifth cranial nerve in headaches
Author
Edvinsson J C A 1   VIAFID ORCID Logo  ; Viganò, A 2 ; Alekseeva, A 3 ; Alieva, E 4 ; Arruda, R 5 ; De, Luca C 6 ; D’Ettore N 7 ; Frattale, I 8 ; Kurnukhina, M 9 ; Macerola, N 10 ; Malenkova, E 11 ; Maiorova, M 12 ; Novikova, A 13 ; Řehulka, P 14 ; Rapaccini, V 15 ; Roshchina, O 3 ; Vanderschueren, G 16 ; Zvaune, L 17 ; Andreou, A P 18 ; Haanes, K A 19 

1  Glostrup Research Institute, Department of Clinical Experimental Research, Glostrup, Denmark; University of Copenhagen, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, Copenhagen, Denmark (GRID:grid.5254.6) (ISNI:0000 0001 0674 042X) 
2  IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy (GRID:grid.5254.6) 
3  First Pavlov State Medical University of St.Petersburg, Department of Neurology, St.Petersburg, Russia (GRID:grid.412460.5) 
4  GBUZ Regional Clinical Hospital № 2, Krasnodar, Russia (GRID:grid.412460.5) 
5  University of Sao Paulo, Department of Neuroscience, Ribeirao Preto, Brazil (GRID:grid.11899.38) (ISNI:0000 0004 1937 0722) 
6  University of Pisa, Department of Clinical and Experimental Medicine, Neurology Unit, Pisa, Italy (GRID:grid.5395.a) (ISNI:0000 0004 1757 3729); University of Campania-Luigi Vanvitelli, Department of Public Medicine, Laboratory of Morphology of Neuronal Network, Naples, Italy (GRID:grid.9841.4) (ISNI:0000 0001 2200 8888) 
7  University of Rome, Tor Vergata, Department of Neurology, Rome, Italy (GRID:grid.6530.0) (ISNI:0000 0001 2300 0941) 
8  University of L’Aquila, Department of Applied Clinical Sciences and Biotechnology, L’Aquila, Italy (GRID:grid.158820.6) (ISNI:0000 0004 1757 2611) 
9  First Pavlov State Medical University of St.Petersburg, Department of Neurosurgery, St.Petersburg, Russia (GRID:grid.412460.5); The Leningrad Regional State Budgetary Institution of health care “Children’s clinical hospital”, St.Petersburg, Russia (GRID:grid.412460.5) 
10  Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore, Department of Internal Medicine, Rome, Italy (GRID:grid.411075.6) (ISNI:0000 0004 1760 4193) 
11  Petrovsky National Research Centre of Surgery, Pain Department, Moscow, Russia (GRID:grid.411075.6) 
12  University of Tartu, Faculty of Medicine, Tartu, Estonia (GRID:grid.10939.32) (ISNI:0000 0001 0943 7661) 
13  F.F. Erisman Federal Research Center for Hygiene, Mytishchy, Russia (GRID:grid.10939.32) 
14  St. Anne’s University Hospital and Faculty of Medicine, Masaryk University, Department of Neurology, Brno, Czech Republic (GRID:grid.10267.32) (ISNI:0000 0001 2194 0956) 
15  University Hospital Tor Vergata, Child Neurology and Psychiatry Unit, Systems Medicine Department, Rome, Italy (GRID:grid.413009.f); Unità Sanitaria Locale (USL) Umbria 2, Terni, Italy (GRID:grid.413009.f); Headache Center, Ospedale Pediatrico Bambino Gesù, IRCCS, Department of Neurology, Rome, Italy (GRID:grid.414125.7) (ISNI:0000 0001 0727 6809) 
16  Department of Neurology, ZNA Middelheim, Antwerp, Belgium (GRID:grid.417406.0) (ISNI:0000 0004 0594 3542) 
17  Riga Stradins University, Department of Anaesthesiology and Intensive Care, Faculty of Medicine, Riga, Latvia (GRID:grid.17330.36) (ISNI:0000 0001 2173 9398); Hospital Jurmala, Department of Pain Medicine, Jurmala, Latvia (GRID:grid.17330.36); Headache Centre Vivendi, Riga, Latvia (GRID:grid.17330.36) 
18  Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Headache Research, Wolfson CARD, London, UK (GRID:grid.13097.3c) (ISNI:0000 0001 2322 6764); The Headache Centre, Guy’s and St Thomas, NHS Foundation Trust, London, UK (GRID:grid.451052.7) (ISNI:0000 0004 0581 2008) 
19  Glostrup Research Institute, Department of Clinical Experimental Research, Glostrup, Denmark (GRID:grid.451052.7) 
Publication year
2020
Publication date
Dec 2020
Publisher
Springer Nature B.V.
ISSN
11292369
e-ISSN
11292377
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1186/s10194-020-01134-1
ProQuest document ID
2409814899
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.