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Abstract
One of the triggers for the disruption of the follicle maturation process along with the oocyte core is the presence of reactive oxygen species (ROS) can affect oxidative stress caused by substances in cigarette smoke. Female passive smokers experience menstrual disorders in the reproductive system, less fetal weight and other reproductive problems. The reality in the community, smoking habits are still difficult to stop, even though health workers and the media have often been socializing about the dangers of cigarette smoke.
The aim of study was to explain the effect of cigarette smoke on damage to theca cells in follicles in the ovaries in balb / c mice exposed to cigarette smoke. The subjects used in this study were 20 mice (Mus Musculus) Balbb / c females aged around 8-10 weeks with a bodyweight of 2530 grams . he results showed the test statistic Mann Whithney smoke increased MDA (Malondeldehide) levels (P= .000), decreased GnRH (Gonadothrophin Relesing Hormone) levels (P= .000) and increased the theca cell apoptosis index (P= .000), and the results of the Independent T-statistic test results Tests showed that exposure to cigarette smoke decreased HSP (Heat Shock Protein) 70 expression (P= .002) and decreased the number of follicles in the ovary (P= .004).
Experimental article (J Int Dent Med Res 2020; 13(2): 774-777) I
Keywords: Follicles, Mice, Cigarette Smoke, MDA, GnRH, HSP 70, Apoptosis.
Received date: 09 December 2019' Accept date: 19 January 2020 I
Introduction
Infertility is a problem for women and men throughout the world. The prevalence of causes of infertility in women according to WHO among them is ovulation disorders 33%. Disruption of the process of ovulation is caused by disorders of the hypothalamus-pituitary, ovary, and endometrium, resulting in disruption of the follicular maturation process and impaired implantation. One of the triggers for oocyte maturation process disruption is the presence of ROS which can affect the occurrence of oxidative stress, one of which is caused by substances contained in cigarette smoke. Cigarette smoke contains 4800 kinds of dangerous chemical compounds and one of them is free radicals1,22. Hot steam in cigarette smoke can enter the respiratory tract, then react with NOX to NADPH oxidase and O2 O (superoxide). There are no product standards that for controlling the...