Monocytes;
Receptors;
Steroids;
Glucocorticoids;
Immunotherapy;
Lymphocytes T;
Phenotypes;
Ablation;
Cytokines;
Cell differentiation;
Differentiation (biology);
Genotype & phenotype;
Melanoma;
Macrophages;
Active control;
Cell activation;
Lymphocytes;
Tumors;
Gene expression;
Steroidogenesis;
Biosynthesis;
Signaling;
Hepatocyte nuclear factor 1;
Cancer;
Transcription activation;
Immune checkpoint;
Tumor-infiltrating lymphocytes;
CD8 antigen;
Cancer immunotherapy;
Growth inhibition

Endogenous Glucocorticoid Signaling Regulates CD8 + T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

Acharya, Nandini ¹ ; Madi, Asaf ² ; Zhang, Huiyuan ¹ ; Klapholz, Max ¹ ; Escobar, Giulia ¹ ; Dulberg, Shai ³ ; Christian, Elena ⁴ ; Ferreira, Michelle ⁵ ; Dixon, Karen O ¹ ; Fell, Geoffrey ⁶ ; Tooley, Katherine ¹ ; Mangani, Davide ¹ ; Xia, Junrong ¹ ; Singer, Meromit ⁷ ; Bosenberg, Marcus ⁵ ; Neuberg, Donna ⁶ ; Rozenblatt-Rosen, Orit ⁸ ; Regev, Aviv ⁹ ; Kuchroo, Vijay K ¹ ; Anderson, Ana C <sup>1 

1</sup>  Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA 
²  Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA; Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 
³  Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 
⁴  Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA 
⁵  Departments of Dermatology, Pathology, and Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA 
⁶  Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 01225, USA 
⁷  Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA 
⁸  Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA 
⁹  Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Koch Institute and Ludwig Center, Massachusetts Institute of Technology, Cambridge, MA 02142, USA 

Immunity; Cambridge

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