Abstract

Physical activity (PA) is one of the most important modifiable factors associated with fracture risk. However, the association between interval changes in PA and the risk of fracture remains unknown. We investigated the risk of fracture development according to interval changes in PA in middle aged and older individuals. In this nationwide cohort study of adults aged ≥ 40 years, more than 4.9 million individuals without fractures within the last year who underwent two consecutive national health screenings in Korea from 2009 to 2012 were identified. The risk of fracture between 2013 and 2016 according to interval changes in regular PA was prospectively analyzed. Compared to individuals with a continuous lack of PA, those with a decrease in PA (0.41/1000 person-years (PY) decrease in incidence rate (IR); adjusted hazard ratio (aHR) 0.975; 95% confidence interval (CI) 0.964–0.987), increase in PA (1.8/1000 PY decrease in IR; aHR 0.948; 95% CI 0.937–0.959), and continuous PA (3.58/1000 PY decrease in IR; aHR 0.888; 95% CI 0.875–0.901) had a significantly reduced risk of fracture. Interval changes in regular PA were associated with risk of fracture. Individuals who engaged in continuous regular PA exhibited the maximum protective benefit against fracture.

Details

Title
Changes in physical activity and risk of fracture: a Korean nationwide population-based cohort study
Author
Han Sangsoo 1 ; Hae-Dong, Jang 2 ; Choi, Sungwoo 1 ; Kim, Gi Deok 2 ; Han Kyungdo 3 ; Lim Hyunwoong 4 ; Koo Bongmo 5 ; Min Kyung Dae 2 ; Jae-Young, Hong 5 

 Soonchunhyang University Bucheon Hospital, Department of Emergency Meidcine, Bucheon, Republic of Korea (GRID:grid.412678.e) (ISNI:0000 0004 0634 1623) 
 Soonchunhyang University Bucheon Hospital, Department of Orthopaedic Surgery, Bucheon, Republic of Korea (GRID:grid.412678.e) (ISNI:0000 0004 0634 1623) 
 Catholic University, Department of Biostatistics, College of Medicine, Seoul, Republic of Korea (GRID:grid.411947.e) (ISNI:0000 0004 0470 4224) 
 Korea University, Department of Industrial Management Engineering, Seoul, Republic of Korea (GRID:grid.222754.4) (ISNI:0000 0001 0840 2678) 
 Korea University Hospital, Ansan, Department of Orthopedics, Ansan-si, Republic of Korea (GRID:grid.411134.2) (ISNI:0000 0004 0474 0479) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2449451690
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.