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Abstract:
Carbazole skeleton is the key structural motif of many biologically active compounds including synthetic and natural products. Carbazole has a good attention in the field of research study due to the wide spectrum of biological activity and therapeutic applications. Carbazole is a good lead compound for the synthesis of novel drugs. There is a growing interest in the synthesis of several carbazole derivatives as better drug candidates for the treatment of various diseases. Carbazole contains a strong pharmacophoric moiety and ring structure which attracts the researcher to this nucleus for the synthesis of novel drugs. Through this review, it introduces a new way for a researcher for introducing this nucleus and develop a novel class of drugs who have better therapeutic profile. In this review, it mainly discusses about the pharmacological activity of carbazole which has already been discussed by the researcher. These reports have resulted in a great number of contributions in diverse areas of interest. This study may produce a new way for the researchers to design and develop carbazole derivatives with good pharmacological activities.
Keywords: Anticancer , antiepileptic, antimicrobial , carbazole
INTRODUCTION:
Carbazole is a nitrogen containing heterocyclic compounds. It has a tricyclic structure, that consists of two 6 membered benzene ring fused on either side with a nitrogen-containing five membered ring. Carbazole and its derivatives are very important type of nitrogen containing heterocyclic compounds that are widespread in nature. The Carbazole ring is present in a variety of naturally occurring medicinally active substances e.g., carbazomycins and murrayafoline A. Various carbazole derivatives such as benzocarbazoles, oxazinocarbazoles, tetrahydrocarbazoles, furo-carbazoles, pyridocarbazoles, pyrrolocarbazoles, indolocarbazoles, oxazolinylcarbazoles, thienocarbazoles, imidazocarbazoles, thiazolocarbazoles , benzopyrano-carbazoles, benzofurano-carbazoles and Nsubstituted carbazoles have been synthesized and are well known for their pharmacological activities.Several research studies are focused on carbazole nucleus due to their wide applicability. Carbazole derivatives are promising drug candidate for the treatment of various diseases. The pharmacological activities exhibited by carbazolesare anti-cancer, antibacterial, antifungal, antiinflammatory, anti-histaminic, antioxidant, hepatoprotective, anti-HIV, antiprotozoan, anti-tubercular, anti-epileptic and sedative properties, or topoisomerase II inhibition ability.[1,2]
Carbazole derivatives act as intermediate for the synthesis of many compounds and also it is the starting material for the design of novel drugs. Carbazole forms different derivatives with interesting biological properties due to the presence of better pharmacophoric...