Abstract

BACKGROUND: Several predictors of clinical outcomes after percutaneous transluminal angioplasty (PTA) interventions in patients with peripheral arterial disease (PAD) have been investigated. Indices of endothelial function, arterial pulse waveform analysis (aPWA) and markers of peripheral artery ischemia were among the most commonly examined. The aim of the current study was to assess the relationship between potential predictors of clinical outcomes after peripheral artery PTA during a 1-year follow-up period.
METHODS: The study included 72 individuals with PAD at a mean age of 66.3 ± 7.2 (79.1% males). All patients underwent PTA of the peripheral arteries. Among them, 42.8% presented critical limb ischemia (CLI). During the first visit and at 1 month and 6 months after PTA, endothelial function and aPWA measurements were taken. Ankle-brachial index (ABI), toe-brachial index (TBI) and physical evalu­ation of the limbs took place during the first visit and at 1, 6 and 12 months after the PTA. The study endpoints included myocardial infarction, amputation, death, stroke and reintervention. All subjects included in the study were observed for 386 days after the PTA.
RESULTS: A significant improvement was noted in walking distance after PTA at the following time points, as well as transient improvement of ABI and flow-mediated dilatation (FMD) and no significant change in aPWA indices and reactive-hyperaemia index (RHI). The mean ABI, TBI, FMD and RHI values did not correlate with each other at baseline. There were 25 study endpoints which occurred in 16 patients during the follow-up period (22.2%). Patients with CLI, hypercholesterolemia, lower dias­tolic blood pressure, higher subendocardial viability ratio, a greater number of pack-years and lower TBI at baseline presented significantly poorer clinical outcomes in terms of endpoint events.
CONCLUSIONS: Endothelial function assessed as FMD and reactive hyperemia–peripheral arterial tonometry (RH-PAT) before PTA in patients with advanced PAD do not predict clinical outcomes during the 1-year follow-up.

Details

Title
The relationship between pulse waveform analysis indices, endothelial function and clinical outcomes in patients with peripheral artery disease treated using percutaneous transluminal angioplasty during a one-year follow-up period
Author
Kaczmarczyk, Paweł 1 ; Maga, Paweł 2 ; Niżankowski, Rafał 3 ; Januszek, Rafał 4 ; Frołow, Marzena 3 ; Maga, Mikołaj 3 ; Kościelniak, Jolanta 2 ; Belowski, Andrzej 2 

 Angio-Medicus Treatment Facility, Krakow, Poland. [email protected] 
 Angio-Medicus Treatment Facility, Krakow, Poland 
 Department of Angiology, Jagiellonian University Medical College, Krakow, Poland 
 2nd Department of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland 
First page
142
End page
151
Publication year
2020
Publication date
2020
Publisher
Wydawnictwo Via Medica
ISSN
18975593
e-ISSN
1898018X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2464203970
Copyright
© 2020. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.