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Abstract
As of 1st June 2020, the US Centres for Disease Control and Prevention reported 104,232 confirmed or probable COVID-19-related deaths in the US. This was more than twice the number of deaths reported in the next most severely impacted country. We jointly model the US epidemic at the state-level, using publicly available death data within a Bayesian hierarchical semi-mechanistic framework. For each state, we estimate the number of individuals that have been infected, the number of individuals that are currently infectious and the time-varying reproduction number (the average number of secondary infections caused by an infected person). We use changes in mobility to capture the impact that non-pharmaceutical interventions and other behaviour changes have on the rate of transmission of SARS-CoV-2. We estimate that Rt was only below one in 23 states on 1st June. We also estimate that 3.7% [3.4%–4.0%] of the total population of the US had been infected, with wide variation between states, and approximately 0.01% of the population was infectious. We demonstrate good 3 week model forecasts of deaths with low error and good coverage of our credible intervals.
High numbers of COVID-19-related deaths have been reported in the United States, but estimation of the true numbers of infections is challenging. Here, the authors estimate that on 1 June 2020, 3.7% of the US population was infected with SARS-CoV-2, and 0.01% was infectious, with wide variation by state.
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1 Abdul Latif Jameel Institute for Disease and Emergency Analytics (J-IDEA), Imperial College, MRC Centre for Global Infectious Disease Analysis, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111)
2 University of Oxford, Department of Statistics, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)
3 Imperial College, Department of Mathematics, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111)
4 Abdul Latif Jameel Institute for Disease and Emergency Analytics (J-IDEA), Imperial College, MRC Centre for Global Infectious Disease Analysis, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111); London School of Hygiene and Tropical Medicine, Department of Infectious Disease Epidemiology, London, UK (GRID:grid.8991.9) (ISNI:0000 0004 0425 469X)
5 Imperial College London, NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111)
6 Imperial College, MRC Centre for Global Infectious Disease Analysis, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111)
7 Abdul Latif Jameel Institute for Disease and Emergency Analytics (J-IDEA), Imperial College, MRC Centre for Global Infectious Disease Analysis, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111); University of Sussex, School of Life Sciences, Brighton, UK (GRID:grid.12082.39) (ISNI:0000 0004 1936 7590)
8 Abdul Latif Jameel Institute for Disease and Emergency Analytics (J-IDEA), Imperial College, MRC Centre for Global Infectious Disease Analysis, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111); Brown University, Department of Laboratory Medicine and Pathology, Providence, USA (GRID:grid.40263.33) (ISNI:0000 0004 1936 9094)
9 Abdul Latif Jameel Institute for Disease and Emergency Analytics (J-IDEA), Imperial College, MRC Centre for Global Infectious Disease Analysis, London, UK (GRID:grid.7445.2) (ISNI:0000 0001 2113 8111); University of Oxford, Department of Statistics, Oxford, UK (GRID:grid.4991.5) (ISNI:0000 0004 1936 8948)