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Abstract
The purpose of this research was to identify metabolite change during barley (Hordeum vulgare) germination and reveal active principles for the anti-wrinkle activity. Barley was germinated with deionized water (DW) and mineral-rich water (MRW) for the comparison of the effect of mineral contents on the metabolites changes during germination. The effects of germinated barley extracts (GBEs) on collagen production and collagenase inhibition were evaluated in vitro using human dermal fibroblasts (HDFs). A pronounced anti-wrinkle activity was observed in the test group treated with the MRW-GBEs. In order to find out the active components related to the anti-wrinkle activity, an orthogonal projection to latent structure-discriminant analysis (OPLS-DA) was performed, using the data from secondary metabolites profiling conducted by UPLC–PDA–ESI–MS. The anti-wrinkle activity of MRW-GBEs was revealed to be associated with the increase of oligomeric compounds of procyanidin and prodelphinidin, indicating that it can be used as an active ingredient for anti-wrinkle agents.
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1 Kyung Hee University, Department of Life and Nanopharmaceutical Sciences, Seoul, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818)
2 DERMAPRO Ltd., Dermapro Bio Research Center, Jeju-si, Republic of Korea (GRID:grid.289247.2)
3 DERMAPRO Ltd., Dermapro Skin Research Center, Seoul, Republic of Korea (GRID:grid.289247.2)
4 Bio Material Research Team, Cosmax BTI R&I Center, Seongnam-si, Republic of Korea (GRID:grid.289247.2)
5 Durae R&D Center, Durae Corporation, Gunpo-si, Republic of Korea (GRID:grid.289247.2)
6 Jeju Bio Center, Durae Corporation, Jeju-si, Republic of Korea (GRID:grid.289247.2)
7 Kyung Hee University, Department of Life and Nanopharmaceutical Sciences, Seoul, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818); Kyung Hee University, Department of Oriental Pharmaceutical Science, Seoul, Republic of Korea (GRID:grid.289247.2) (ISNI:0000 0001 2171 7818)