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Recurrent floods are one of the major global threats among people, particularly in developing countries like India, as this nation has a tropical monsoon type of climate. Therefore, flood susceptibility (FS) mapping is indeed necessary to overcome this type of natural hazard phenomena. With this in mind, we evaluated the prediction performance of FS mapping in the Koiya River basin, Eastern India. The present research work was done through preparation of a sophisticated flood inventory map; eight flood conditioning variables were selected based on the topography and hydro-climatological condition, and by applying the novel ensemble approach of hyperpipes (HP) and support vector regression (SVR) machine learning (ML) algorithms. The ensemble approach of HP-SVR was also compared with the stand-alone ML algorithms of HP and SVR. In relative importance of variables, distance to river was the most dominant factor for flood occurrences followed by rainfall, land use land cover (LULC), and normalized difference vegetation index (NDVI). The validation and accuracy assessment of FS maps was done through five popular statistical methods. The result of accuracy evaluation showed that the ensemble approach is the most optimal model (AUC = 0.915, sensitivity = 0.932, specificity = 0.902, accuracy = 0.928 and Kappa = 0.835) in FS assessment, followed by HP (AUC = 0.885) and SVR (AUC = 0.871).