Abstract
Furthermore, not only the dilated kidney tubules and ectatic Bowman spaces, but also the dark needle-like urate crystals, focal tubulointerstitial fibrosis and glycometabolic disorder were more evident in the kidneys of mice treated with Ade-100 + OXO-500, further illustrating the more severe kidney injury [Figure 1G and 1H] in this group of mice. Immunohistochemistry of kidneys from mice administrated with adenine and OXO showed massive accumulation of URAT1 and GLUT9 in injured tubules, meaning the increase of uric acid re-absorption in the proximal renal tubules. [...]we attempted to create mouse model of hyperuricemia by injecting mouse with adenine and OXO.
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Details
1 Department of Pharmacology, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
2 Guangzhou University of Chinese Medicine, Math Engineering Academic Chinese Medicine, Guangdong Province of Key Lab New Drug Dev & Res Chinese, Guangzhou, Guangdong 510006, China; Guangzhou University of Chinese Medicine, Dongguan Math Engineering Academic Chinese Medicine, Dongguan, Guangdong 523808, China
3 Foshan Santanyi Biotech Co., Ltd, Foshan, Guangdong 528031, China
4 Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
5 Guangzhou University of Chinese Medicine, Dongguan Math Engineering Academic Chinese Medicine, Dongguan, Guangdong 523808, China