Abstract

Background:

In recent years, visual quality has been extensively investigated in various conditions. In this community-based population study, we analyzed the effects of aging, refraction, and Lens Opacification Classification System III (LOCSIII) score on retinal imaging quality in healthy Chinese adults.

Methods:

This cross-sectional study was conducted on sub-group subjects from The Handan Eye Study between October 2012 and January 2013. Healthy subjects over 30-years-old with logarithm of the minimal angle of resolution (logMAR) best-corrected visual acuity (BCVA) less than 0 were included. Retinal image quality was measured by optical quality analysis system (OQAS) and recorded as modulation transfer function cutoff frequency (MTFcutoff), OQAS value (OV) 100%, OV20%, OV9%, Strehl ratio (SR), and objective scatter index (OSI). The correlation between age, spherical equivalent refraction (SE), LOCSIII score, and optical quality parameters were investigated by multivariate analysis.

Results:

Among 1108 verified subjects, 690 subjects (1380 eyes) met the inclusion criteria. Their age ranged from 30 to 76 years, SE ranged from −4.75 to 2.75 D. They were divided into five age groups (30–39, 40–49, 50–59, 60–69, and ≥70 years) for further analysis. After multivariate analysis by mixed-effect linear model, SR (t =  −3.03, P = 0.002), OV20% (t = −2.39, P = 0.017), and OV9% (t = −3.16, P = 0.001) significantly decreased with the increasing age, whereas logMAR BCVA (t = 4.42, P < 0.001) and OSI (t = 4.46, P < 0.001) significantly increased with age. As SE increased, SR (t = 2.74, P = 0.01), OV20% (t = 2.31, P = 0.02), and OV9% (t = 2.79, P = 0.005) significantly elevated, and OSI (t = −3.38, P < 0.001) significantly decreased. With the increase in cortical opacity score, all optical quality parameters except for SR significantly decreased, including MTFcutoff (t = −2.78, P = 0.01), OV100% (t = −2.78, P = 0.005), OV20% (t = −2.60, P = 0.009), and OV9% (t = −2.05, P = 0.040). As posterior sub capsular opacity score increased, MTFcutoff (t = −2.40, P = 0.02) and OV100% (t = −2.40, P = 0.01) significantly decreased, while OSI (t = 7.56, P < 0.001) significantly increased.

Conclusions:

In healthy Chinese adult population, optical quality-related parameters significantly decrease with the increasing age, and OSI significantly increases with age. In normal BCVA subjects, optical quality is significantly impacted by cortical and posterior sub capsular opacity rather than by nuclear opacity.

Details

Title
Analysis of related factors of optical quality in healthy Chinese adults: a community-based population study
Author
Xi-Fang, Zhang; Li-Ya, Qiao; Xiao-Gu, Cai; Xiao-Xia, Li; Jia-Xuan, Tan; Guan, Zheng; Zhang, Ye; Cao, Kai; Ning-Li, Wang
Pages
2308-2314
Section
Original Articles
Publication year
2020
Publication date
Oct 2020
Publisher
Lippincott Williams & Wilkins Ovid Technologies
ISSN
03666999
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2480944216
Copyright
Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.