Abstract

Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve the FAIRness of already existing transcriptomics data for ENMs, we curated a collection of homogenized transcriptomics data from human, mouse and rat ENM exposures in vitro and in vivo including the physicochemical characteristics of the ENMs used in each study.

Measurement(s)

microarray data • transcriptome • RNA • Toxicogenomics

Technology Type(s)

digital curation

Factor Type(s)

exposure to engineered nanomaterials

Sample Characteristic - Organism

Homo sapiens • Mus musculus • Rattus

Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.13154381

Details

Title
Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials
Author
Saarimäki Laura Aliisa 1 ; Federico, Antonio 1 ; Lynch Iseult 2   VIAFID ORCID Logo  ; Papadiamantis, Anastasios G 3 ; Tsoumanis Andreas 4 ; Melagraki Georgia 4 ; Afantitis Antreas 4   VIAFID ORCID Logo  ; Serra, Angela 1 ; Greco, Dario 5   VIAFID ORCID Logo 

1  Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland (GRID:grid.502801.e) (ISNI:0000 0001 2314 6254); Tampere University, BioMediTech Institute, Tampere, Finland (GRID:grid.502801.e) (ISNI:0000 0001 2314 6254) 
2  University of Birmingham, School of Geography, Earth and Environmental Sciences, Edgbaston, United Kingdom (GRID:grid.6572.6) (ISNI:0000 0004 1936 7486) 
3  University of Birmingham, School of Geography, Earth and Environmental Sciences, Edgbaston, United Kingdom (GRID:grid.6572.6) (ISNI:0000 0004 1936 7486); NovaMechanics Ltd, Nicosia, Cyprus (GRID:grid.436662.3) (ISNI:0000 0004 5346 0342) 
4  NovaMechanics Ltd, Nicosia, Cyprus (GRID:grid.436662.3) (ISNI:0000 0004 5346 0342) 
5  Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland (GRID:grid.502801.e) (ISNI:0000 0001 2314 6254); Tampere University, BioMediTech Institute, Tampere, Finland (GRID:grid.502801.e) (ISNI:0000 0001 2314 6254); University of Helsinki, Institute of Biotechnology, Helsinki, Finland (GRID:grid.7737.4) (ISNI:0000 0004 0410 2071); Faculty of Medicine and Heath Technology, Tampere University, Finnish Centre for Alternative Methods (FICAM), Tampere, Finland (GRID:grid.502801.e) (ISNI:0000 0001 2314 6254) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20524463
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41597-021-00808-y
ProQuest document ID
2487165230
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.