Abstract

Mapping the causal effects of one brain region on another is a challenging problem in neuroscience that we approached through invasive direct manipulation of brain function together with concurrent whole-brain measurement of the effects produced. Here we establish a unique resource and present data from 26 human patients who underwent electrical stimulation during functional magnetic resonance imaging (es-fMRI). The patients had medically refractory epilepsy requiring surgically implanted intracranial electrodes in cortical and subcortical locations. One or multiple contacts on these electrodes were stimulated while simultaneously recording BOLD-fMRI activity in a block design. Multiple runs exist for patients with different stimulation sites. We describe the resource, data collection process, preprocessing using the fMRIPrep analysis pipeline and management of artifacts, and provide end-user analyses to visualize distal brain activation produced by site-specific electrical stimulation. The data are organized according to the brain imaging data structure (BIDS) specification, and are available for analysis or future dataset contributions on openneuro.org including both raw and preprocessed data.

Measurement(s)

brain measurement • anatomical image data • functional brain measurement

Technology Type(s)

magnetic resonance imaging (MRI) • functional magnetic resonance imaging

Factor Type(s)

pre-surgery versus post-surgery • electrical stimulation (on vs off)

Sample Characteristic - Organism

Homo sapiens

Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare.12625541

Details

Title
A data resource from concurrent intracranial stimulation and functional MRI of the human brain
Author
Thompson, W H 1   VIAFID ORCID Logo  ; Nair, R 2   VIAFID ORCID Logo  ; Oya, H 3 ; Esteban, O 4   VIAFID ORCID Logo  ; Shine, J M 5   VIAFID ORCID Logo  ; Petkov, C I 6   VIAFID ORCID Logo  ; Poldrack R A 4 ; Howard, M 3 ; Adolphs, R 2 

1  Stanford University, Department of Psychology, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956); Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden (GRID:grid.4714.6) (ISNI:0000 0004 1937 0626) 
2  California Institute of Technology, Division of Humanities and Social Sciences, Pasadena, USA (GRID:grid.20861.3d) (ISNI:0000000107068890) 
3  University of Iowa, Department of Neurosurgery, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294); University of Iowa, Iowa Neuroscience Institute, Iowa City, USA (GRID:grid.214572.7) (ISNI:0000 0004 1936 8294) 
4  Stanford University, Department of Psychology, Stanford, USA (GRID:grid.168010.e) (ISNI:0000000419368956) 
5  The University of Sydney, Brain and Mind Centre, Sydney, Australia (GRID:grid.1013.3) (ISNI:0000 0004 1936 834X) 
6  Newcastle University Medical School, Newcastle Upon Tyne, UK (GRID:grid.1006.7) (ISNI:0000 0001 0462 7212) 
Publication year
2020
Publication date
2020
Publisher
Nature Publishing Group
e-ISSN
20524463
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41597-020-00595-y
ProQuest document ID
2489906130
Copyright
© The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.