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Abstract
Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.
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1 Postal Hospital, Department of Urology, Taipei, Taiwan; Taiwan Adventist Hospital, Department of Urology, Taipei, Taiwan (GRID:grid.416851.f) (ISNI:0000 0004 0573 0926)
2 The Buddhist Tzu Chi Medical Foundation, Division of Urology, Department of Surgery, Taipei Tzuchi Hospital, New Taipei City, Taiwan (GRID:grid.416851.f); Buddhist Tzu Chi University, School of Medicine, Hualien, Taiwan (GRID:grid.411824.a) (ISNI:0000 0004 0622 7222)
3 Kaohsiung Municipal Ta-Tung Hospital, Department of Urology, Kaohsiung, Taiwan (GRID:grid.415007.7) (ISNI:0000 0004 0477 6869); Kaohsiung Medical University Hospital, Department of Urology, Kaohsiung, Taiwan (GRID:grid.412027.2) (ISNI:0000 0004 0620 9374); Kaohsiung Medical University, Department of Urology, School of Medicine, College of Medicine, Kaohsiung, Taiwan (GRID:grid.412019.f) (ISNI:0000 0000 9476 5696)
4 Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Department of Urology, Hualien Tzu Chi Hospital, Hualien, Taiwan (GRID:grid.411824.a) (ISNI:0000 0004 0622 7222)
5 Cardinal Tien Hospital, Division of Urology, Department of Surgery, New Taipei City, Taiwan (GRID:grid.413400.2) (ISNI:0000 0004 1773 7121); Fu-Jen Catholic University, Department of Urology, School of Medicine, Taipei, Taiwan (GRID:grid.256105.5) (ISNI:0000 0004 1937 1063)
6 Taipei Medical University, Department of Urology, Shuang Ho Hospital, New Taipei City, Taiwan (GRID:grid.412896.0) (ISNI:0000 0000 9337 0481); Taipei Medical University, Department of Urology, School of Medicine, College of Medicine, Taipei, Taiwan (GRID:grid.412896.0) (ISNI:0000 0000 9337 0481)
7 National Taiwan University, Department of Urology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan (GRID:grid.19188.39) (ISNI:0000 0004 0546 0241)
8 Chang Gung Memorial Hospital, Division of Urology, Department of Surgery, Puzi City, Taiwan (GRID:grid.19188.39); Chang Gung University of Science and Technology, Puzi City, Taiwan (GRID:grid.418428.3); Chang Gung University, Department of Medicine, Taoyuan, Taiwan (GRID:grid.145695.a)
9 Taipei Medical University, Department of Urology, School of Medicine, College of Medicine, Taipei, Taiwan (GRID:grid.412896.0) (ISNI:0000 0000 9337 0481)
10 Taipei Medical University, Department of Urology, School of Medicine, College of Medicine, Taipei, Taiwan (GRID:grid.412896.0) (ISNI:0000 0000 9337 0481); Taipei Medical University, Department of Urology, Taipei Medical University Hospital, Taipei City, Taiwan (GRID:grid.412896.0) (ISNI:0000 0000 9337 0481)