Abstract

Data storage in DNA is a rapidly evolving technology that could be a transformative solution for the rising energy, materials, and space needs of modern information storage. Given that the information medium is DNA itself, its stability under different storage and processing conditions will fundamentally impact and constrain design considerations and data system capabilities. Here we analyze the storage conditions, molecular mechanisms, and stabilization strategies influencing DNA stability and pose specific design configurations and scenarios for future systems that best leverage the considerable advantages of DNA storage.

DNA has the potential to store vast amounts of data but it is subject to physical decay. In this Perspective, the authors propose that the stability of DNA should be a key consideration in how it is used for data storage.

Details

Title
DNA stability: a central design consideration for DNA data storage systems
Author
Matange Karishma 1   VIAFID ORCID Logo  ; Tuck, James M 2   VIAFID ORCID Logo  ; Keung, Albert J 1   VIAFID ORCID Logo 

1  North Carolina State University, Department of Chemical and Biomolecular Engineering, Raleigh, USA (GRID:grid.40803.3f) (ISNI:0000 0001 2173 6074) 
2  North Carolina State University, Department of Electrical and Computer Engineering, Raleigh, USA (GRID:grid.40803.3f) (ISNI:0000 0001 2173 6074) 
Publication year
2021
Publication date
2021
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-021-21587-5
ProQuest document ID
2494705723
Copyright
© The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.