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Abstract
A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole alkaloid, named lagerindicine (1), along with four known compounds (2–5). Their structures were elucidated by the detailed spectroscopic analysis and comparison with literature data, whereas the structure, in particularly, the absolute configuration (AC) of 1, was firmly determined by total synthesis. All the isolates were evaluated for their cytotoxic effects against human colon cancer cell (HCT-116), and compound 3 exhibited weak cytotoxicity with IC50 value of 28.4 μM.
Graphic Abstract
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Details
1 Hunan Academy of Forestry, Changsha, China; Changsha Engineering Technology Research Center of Woody Flower, Changsha, China
2 Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai, China (GRID:grid.9227.e) (ISNI:0000000119573309)
3 Hunan Academy of Forestry, Changsha, China (GRID:grid.9227.e); Changsha Engineering Technology Research Center of Woody Flower, Changsha, China (GRID:grid.9227.e)
4 Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai, China (GRID:grid.9227.e) (ISNI:0000000119573309); Central South University of Forestry and Technology, College of Materials Science and Engineering, Changsha, China (GRID:grid.440660.0) (ISNI:0000 0004 1761 0083)