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Abstract
Primary prevention of premature death is a public health concern worldwide. Circulating microRNAs (miRNAs) have been described as potential diagnostic biomarkers for diseases as cancer and cardiovascular disease (CVD). This case-cohort study aimed to investigate the potential relationship between circulating miRNAs and the risk of premature death. A total of 39,242 subjects provided baseline serum samples in 1988–1990. Of these, 345 subjects who died of intrinsic disease (< 65 years old) and for which measurable samples were available were included in this study. We randomly selected a sub-cohort of 879 subjects. Circulatring miR-21, miR-29a, and miR-126 were determined using qRT-PCR. Conditional logistic regression models were used to analyse the data with respect to stratified miRNA levels. Multivariable logistic regression revealed that subjects with high circulating miR-21 and miR-29a individual levels had a significantly higher risk of total death, cancer death, and CVD death than those with medium miR-21 and miR-29a individual levels. Conversely, subjects with low circulating miR-126 levels had a significantly higher risk of total death than those with medium levels. This suggests that circulating miRNAs are associated with the risk of premature death from cancer and CVD, identifying them as potential biomarkers for early detection of high-risk individuals.
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1 Fujita Health University School of Medicine, Department of Hygiene, Toyoake, Japan (GRID:grid.256115.4) (ISNI:0000 0004 1761 798X)
2 Fujita Health University School of Health Sciences, Department of Preventive Medical Sciences, Toyoake, Japan (GRID:grid.256115.4) (ISNI:0000 0004 1761 798X)
3 Kyoto Prefectural University of Medicine, Department of Epidemiology for Community Health and Medicine, Graduate School of Medical Science, Kyoto, Japan (GRID:grid.272458.e) (ISNI:0000 0001 0667 4960)
4 Osaka University Graduate School of Medicine, Public Health, Department of Social Medicine, Osaka, Japan (GRID:grid.136593.b) (ISNI:0000 0004 0373 3971)
5 University of Occupational and Environmental Health, Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, Kitakyushu, Japan (GRID:grid.271052.3) (ISNI:0000 0004 0374 5913)
6 Nagoya University Graduate School of Medicine, Department of Preventive Medicine, Nagoya, Japan (GRID:grid.27476.30) (ISNI:0000 0001 0943 978X)
7 Hokkaido University Graduate School of Medicine, Department of Public Health, Sapporo, Japan (GRID:grid.39158.36) (ISNI:0000 0001 2173 7691)