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© 2021 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Results SND1 contributes to protection against chlamydial lung infection To assess the role played by SND1 in host defense against chlamydial infection, a group of SND1-/-(homozygous), SND1+/-(heterozygous) and wild-type control mice on a C57BL/6 background was intranasally administered with Cm. The lung histological analysis showed much more tissue damage and pathological change in the SND1-/- mice than in SND1+/- and wild-type mice, meanwhile there was no difference in lung histological structure among the mice of SND1-/-, SND1+/- and wild-type control mice (Fig 1C), which was further quantified by measuring the mean linear intercept (MLI), an indicator of alveolar space shown in Fig 1D. Greater body weight loss, higher bacterial growth, and more severe pathological changes in the lungs of SND1-/- mice compared with that in heterozygous and control C57BL/6 mice following Cm lung infection. Results are shown as mean±SD. *, p <0.05; **, p<0.01.+ indicates as Cm infection. https://doi.org/10.1371/journal.ppat.1009295.g001 SND1-/- mice exhibit reduced Th1/17 Cm-specific immune responses after infection Because previous studies have demonstrated the association of protection with type 1 T cell responses and more severe disease severity/pathology with type 2 T cell responses against Cm infection[4,6,7], we further analyzed the Cm-driven type 1 and type 2 cytokine production by spleen and lung tissue from the infected SND1-/- and wild-type mice in comparison with the sham-treated (PBS control) mice.

Details

Title
SND1 promotes Th1/17 immunity against chlamydial lung infection through enhancing dendritic cell function
Author
Wang, Xinting; Zhang, Chunyan  VIAFID ORCID Logo  ; Wang, Shuhe; Rashu, Rasheduzzaman; Rony, Thomas  VIAFID ORCID Logo  ; Yang, Jie  VIAFID ORCID Logo  ; Yang, Xi  VIAFID ORCID Logo 
First page
e1009295
Section
Research Article
Publication year
2021
Publication date
Feb 2021
Publisher
Public Library of Science
ISSN
15537366
e-ISSN
15537374
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2501884374
Copyright
© 2021 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.