Content area
Abstract
Six new butyrolactone derivatives (1, 2a/2b, 3a/3b and 4), together with another two known derivatives (5 and 6) were isolated from the endophytic fungus Talaromyces sp. CPCC 400783. Their structures were established by a combination of spectroscopic analysis, including NMR and HRESIMS. The absolute configurations were elucidated by ECD experiments. Subsequently, compound 1, 3b, 4 and 5 exhibited good inhibitory effect against influenza A/WSN/33 (H1N1) virus with IC50 values of 21.93 ± 1.51, 21.54 ± 3.75, 18.36 ± 2.15 and 23.80 ± 3.05 μM respectively.
Details
Title
New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt
Author
Zhang, Ran 1 ; He Wenni 1 ; Wang, Yujia 2 ; Zhao JianYuan 2 ; Zhou, Rui 2 ; Li, Li 3 ; He Yize 4 ; Cen Shan 2 ; Yu, Liyan 1
1 China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839)
2 Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839)
3 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Medicinal Chemistry, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839)
4 Beijing Union University, College of Biochemical Engineering, Beijing, China (GRID:grid.411618.b) (ISNI:0000 0001 2214 9197)
1 China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839)
2 Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839)
3 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Medicinal Chemistry, Beijing, China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839)
4 Beijing Union University, College of Biochemical Engineering, Beijing, China (GRID:grid.411618.b) (ISNI:0000 0001 2214 9197)
Pages
225-232
Publication year
2021
Publication date
Apr 2021
ISSN
00218820
e-ISSN
18811469
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2506115571
Copyright
© The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2020.