Abstract
Dear Editor, In their anecdotal report, Bossi and colleagues demonstrate that “off-label” use of sodium–glucose cotransporter 2 (SGLT2) inhibitors in three subjects with severe or critical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia without diabetes did not have a significant impact on surrogate clinical outcomes, such as length of hospital stay [1]. [...]current evidence seems insufficient to influence decision-making for the management of patients in the acute setting, especially those without diabetes. Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: a systematic review and meta-analysis.
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1 General Hospital “Hippokration”, Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Thessaloniki, Greece (GRID:grid.4793.9) (ISNI:0000000109457005)
2 General Hospital “Hippokration”, Aristotle University of Thessaloniki, Third Department of Cardiology, Thessaloniki, Greece (GRID:grid.4793.9) (ISNI:0000000109457005)
3 General Hospital “Hippokration”, Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Thessaloniki, Greece (GRID:grid.4793.9) (ISNI:0000000109457005); VAMC and George Washington University, Washington, D.C., USA (GRID:grid.253615.6) (ISNI:0000 0004 1936 9510)