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© 2021 Smith et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

The rate of resistance evolution in a population is directly related to the intensity of the selection pressure, allele frequency, dominance, and relative fitness of the resistance versus susceptible genotypes [6]. Fitness costs can be evaluated either using a population cage study where the resistance levels or resistance allele frequencies of populations are tracked over time, or by measuring individual fitness components, such as survival, reproduction, and growth, in a life history study. Rockefeller (ROCK), a well-studied insecticide-susceptible strain [52], and three permethrin resistant strains with different resistance mechanisms (originating from the Singapore (SP) strain) introgressed into the ROCK genetic background. To examine kdr in combination with CYP-mediated resistance, CKR and ROCK were crossed (Fig 1). Because the mutation causing CYP-mediated resistance is still unknown, we cannot track the CYP resistance genotype, and thus could not repeat this experiment with the

Details

Title
Fitness costs of individual and combined pyrethroid resistance mechanisms, kdr and CYP-mediated detoxification, in Aedes aegypti
Author
Letícia B. Smith Current address: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America  VIAFID ORCID Logo  ; Silva, Juan J  VIAFID ORCID Logo  ; Chen, Connie  VIAFID ORCID Logo  ; Harrington, Laura C  VIAFID ORCID Logo  ; Scott, Jeffrey G  VIAFID ORCID Logo 
First page
e0009271
Section
Research Article
Publication year
2021
Publication date
Mar 2021
Publisher
Public Library of Science
ISSN
19352727
e-ISSN
19352735
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2513691589
Copyright
© 2021 Smith et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.