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Abstract
Epstein–Barr virus (EBV), human herpesvirus 6A/B (HHV-6A/B) and multiple sclerosis (MS)-associated retrovirus (MSRV) have been described as possible MS triggers. We analysed antibody titres against EBV and HHV-6, and MSRV envelope (env) mRNA expression, in the serum of pregnant multiple sclerosis patients (P-MS) to study their possible link to the clinical activity of MS during pregnancy and postpartum and their possible role as relapse predictors. For that purpose, serum samples were collected from 71 pregnant women (50 pregnant MS and 21 pregnant healthy controls—P-HC) during pregnancy and postpartum. Relating to antibody titres, IgM antibody titres against HHV-6A/B were significantly higher in P-MS than in P-HC both in each pregnancy trimester and in the postpartum period. Moreover, IgM antibody titres against HHV-6A/B were higher in P-MS who suffered a relapse during the postpartum. Regarding MSRV env mRNA expression, the prevalence in the first trimester of pregnancy was significantly higher in P-MS who suffered relapses during pregnancy. Summing it up, high IgM antibody titres against HHV-6A/B and MSRV env mRNA expression during the first trimester of pregnancy could act as relapse predictors for the gestation/postpartum periods.
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1 Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC) / Red Española de Esclerosis Múltiple (REEM), Grupo de Investigación de Factores Ambientales en Enfermedades Degenerativas, Madrid, Spain (GRID:grid.414780.e)
2 Hospital Universitario Gregorio Marañón / Red Española de Esclerosis Múltiple (REEM), Servicio de Neurología, Madrid, Spain (GRID:grid.410526.4) (ISNI:0000 0001 0277 7938)
3 Universidad Complutense de Madrid / Red Española de Esclerosis Múltiple (REEM), Instituto de Investigación Sanitaria del Gregorio Marañón / Facultad de Psicología, Madrid, Spain (GRID:grid.4795.f) (ISNI:0000 0001 2157 7667)
4 Instituto de Investigación Sanitaria del Gregorio Marañón / Red Española de Esclerosis Múltiple (REEM), Madrid, Spain (GRID:grid.410526.4) (ISNI:0000 0001 0277 7938)
5 Hospital Universitario Ramón y Cajal/Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) / Red Española de Esclerosis Múltiple (REEM), Servicio de Inmunología, Madrid, Spain (GRID:grid.411171.3) (ISNI:0000 0004 0425 3881)
6 Hospital Universitario Quironsalud Madrid / Red Española de Esclerosis Múltiple (REEM), Departmento de Neurología, Madrid, Spain (GRID:grid.488466.0)