Full text

Turn on search term navigation

© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer´s disease (AD), bipolar disorder (BD) and major depressive disorder (MDD). We examined these groups versus healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and affective disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BP, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.

Details

Title
Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline
Author
Hansen, Niels; Singh, Aditya; Bartels, Claudia; Brosseron, Frederic; Buerger, Katharina; Cetindag, Arda C; Dobisch, Laura; Dechent, Peter; Ertl-Wagner, Birgit B; Fliessbach, Klaus; Haynes, John D; Heneka, Michael T; Janowitz, Daniel; Kilimann, Ingo; Laske, Christoph; Metzger, Coraline D; Munk, Matthias H; Peters, Oliver; Priller, Josef; Roy, Nina; Scheffler, Klaus; Schneider, Anja; Spottke, Annika; Spruth, Eike J; Teipel, Stefan; Tscheuschler, Maike; Vukovich, Ruth; Wiltfang, Jens; Duezel, Emrah; Jessen, Frank; Goya-Maldonado, Roberto
Section
Original Research ARTICLE
Publication year
2021
Publication date
Apr 21, 2021
Publisher
Frontiers Research Foundation
ISSN
16634365
e-ISSN
16634365
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2515925282
Copyright
© 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.