Abstract

Since the first isolation from human, astroviruses have been detected in many species. Wide host range and occasional cross-transmission of astrovirus pose a risk for zoonotic infection. Here, novel astroviruses were identified from goslings with recent epidemic gout disease in China. A virus, designated as GD, was efficiently isolated from a diseased gosling using LMH cells. Genome of GD amplified using 5′ and 3′ RACE was 7183nt in full length. Sequence analysis revealed the genome of GD was <60.8% homology with others deposited in Genbank. Moreover, GD could be neutralized by goose convalescent sera, and the gout associated symptom in goslings could be reproduced by GD infection. Our data demonstrated the goose astrovirus could be one of the causative agents of the ongoing gosling gout disease in China. The identification of the goose astrovirus not only diversified the astrovirus species, but also broadened the disease patterns caused by astroviruses.

Details

Title
An emerging novel goose astrovirus associated with gosling gout disease, China
Author
Zhang, Xinyu 1 ; Ren, Dan 1 ; Li, Tuofan 1 ; Zhou, Huayan 2 ; Liu, Xiaoyu 2 ; Wang, Xiaobo 2 ; Lu, Hao 1 ; Gao, Wei 1 ; Wang, Yajuan 2 ; Zou, Xiaoyan 2 ; Sun, Huaichang 2 ; Ye, Jianqiang 1 

 College of Veterinary Medicine Yangzhou University 225009 Yangzhou Jiangsu China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses 225009 Yangzhou Jiangsu China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China Yangzhou University 225009 Yangzhou Jiangsu China; Institutes of Agricultural Science and Technology Development Yangzhou University 225009 Yangzhou Jiangsu China 
 College of Veterinary Medicine Yangzhou University 225009 Yangzhou Jiangsu China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses 225009 Yangzhou Jiangsu China 
Pages
1-8
Publication year
2018
Publication date
Dec 2018
Publisher
Taylor & Francis Ltd.
e-ISSN
22221751
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2516067748
Copyright
© The Author(s) 2018. This work is licensed under the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.