It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Immune-mediated inflammatory diseases are characterized by variability in disease presentation and severity but studying it is a challenging task. Defining the limits of a healthy immune system is therefore a prior step to capture variability in disease conditions. The goal of this study is to characterize the global immune cell composition along with their influencing factors. Blood samples were collected from 2 independent cohorts of respectively 389 (exploratory) and 208 (replication) healthy subjects. Twelve immune cells were measured in blood together with biological parameters. Three complementary clustering approaches were used to evaluate if variability related to the immune cells could be characterized as clusters or as a continuum. Large coefficients of variation confirmed the inter-individual variability of immune cells. Considering all subset variations in an overall analysis, it appeared that the immune makeup was organized as a continuum through the two cohorts. Some intrinsic and environmental factors affected the inter-individual variability of cells but without unveiling separable groups with similar features. This study provides a framework based on complementary clustering approach for analyzing inter-individual variability of immune cells. Our analyses support the absence of clusters in our two healthy cohorts. Also, our study reports some influence of age, gender, BMI, cortisol, season and CMV infection on immune variability.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details
1 ULB, Laboratory of Experimental Gastroenterology, Brussels, Belgium (GRID:grid.4989.c) (ISNI:0000 0001 2348 0746); Hôpital Erasme, ULB, Department of Gastroenterology, Brussels, Belgium (GRID:grid.412157.4) (ISNI:0000 0000 8571 829X)
2 Umons, Electrical Power Engineering Unit, Mons, Belgium (GRID:grid.8364.9) (ISNI:0000 0001 2184 581X)
3 GIGA-Institute, ULiege, Unit of Animal Genomics, Liège, Belgium (GRID:grid.4861.b) (ISNI:0000 0001 0805 7253)
4 ULB, Laboratory of Experimental Gastroenterology, Brussels, Belgium (GRID:grid.4989.c) (ISNI:0000 0001 2348 0746)