Simplified frontal EEG in adults under veno-arterial extracorporeal membrane oxygenation

Abstract

Background

EEG-based prognostication studies in intensive care units often rely on a standard 21-electrode montage (_stdEEG) requiring substantial human, technical, and financial resources. We here evaluate whether a simplified 4-frontal electrode montage (_4-frontEEG) can detect EEG patterns associated with poor outcomes in adult patients under veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

Methods

We conducted a reanalysis of EEG data from a prospective cohort on 118 adult patients under VA-ECMO, in whom EEG was performed on admission to intensive care. EEG patterns of interest included background rhythm, discontinuity, reactivity, and the Synek’s score. They were all reassessed by an intensivist on a _4-frontEEG montage, whose analysis was then compared to an expert’s interpretation made on _stdEEG recordings. The main outcome measure was the degree of correlation between _4-frontEEG and _stdEEG montages to identify EEG patterns of interest. The performance of the Synek scores calculated on _4-frontEEG and _stdEEG montage to predict outcomes (i.e., 28-day mortality and 90-day Rankin score $\ge 4$) was investigated in a secondary exploratory analysis.

Results

The detection of EEG patterns using _4-frontEEG was statistically similar to that of _stdEEG for background rhythm (Spearman rank test, ρ = 0.66, p < 0.001), discontinuity (Cohen’s kappa, $\kappa$ = 0.955), reactivity ($\kappa$ = 0.739) and the Synek’s score (ρ = 0.794, p < 0.001). Using the Synek classification, we found similar performances between _4-frontEEG and _stdEEG montages in predicting 28-day mortality (AUC _4-frontEEG 0.71, AUC _stdEEG 0.68) and for 90-day poor neurologic outcome (AUC _4-frontEEG 0.71, AUC _stdEEG 0.66). An exploratory analysis confirmed that the Synek scores determined by 4 or 21 electrodes were independently associated with 28-day mortality and poor 90-day functional outcome.

Conclusion

In adult patients under VA-ECMO, a simplified 4-frontal electrode EEG montage interpreted by an intensivist, detected common EEG patterns associated with poor outcomes, with a performance similar to that of a standard EEG montage interpreted by expert neurophysiologists. This simplified montage could be implemented as part of a multimodal evaluation for bedside prognostication.